Works with the body as a political landscape through behavior art, performance, installation and video. Her recent work uses behavior as its principal source to study emotional and social perception. She has been a participant in Documenta 11 (Germany) as well as in several biennials such as Venice (Italy), Johannesburg (South Africa), São Paulo (Brazil), Shangai (China), Havana (Cuba), and SITE Santa Fe (USA).

Her work has also been exhibited at The New Museum of Contemporary Art (USA); The Museum of Contemporary Art of Chicago (USA); Boijmans van Beuningen Museum (Netherlands); Museum für Moderne Kunst (Germany); Helsinki Art Museum (Finland); The Whitechapel Art Gallery (England); Centro de Arte Contemporáneo Wilfredo Lam (Cuba); and Museo Nacional de Bellas Artes (Cuba). She has performed in venues such as The Kunsthalle Wien (Austria); Stedjlick Museum von Actuele Kunst (Belgium); Museo Ex-Teresa Arte Actual (Mexico); Museo de Bellas Artes (Venezuela); and The Institute of International Visual Art (England).

She has lectured extensively internationally among others at The New School in New York, The School of the Art Institute in Chicago, The Royal College of Art in London and The Museum of Modern Art in New York.

In 1998 she was selected as a Guggenheim fellow (USA). In 2000 and 2008 she received the Prince Klaus Prize (Netherlands).

Her work is part of the collection of the Museum für Moderne Kunst (Germany); Daros Foundation (Switzerland); JP Morgan Chase Bank (USA); Museum of Modern Art, artist book collection (USA); Bronx Museum (USA); Museo Nacional de Bellas Artes (Cuba); centro de Arte Contemporáneo Wilfredo Lam (Cuba); The New Museum for Latin American Art (England).

Bruguera was featured in Fresh Cream (Ed. Phaidon, England); Performance Live Art since 1060’s (Ed. Thames and Hudson, Ltd., England); Art Tomorrow (Ed. Terrail, France); Holy Terrors: Latin American Women Performe (Ed. Duke University, USA); Corpus Delecti: Performance Art of the Americas (Ed. Routledge, England); New Art of Cuba (Ed. University of Texas Press, USA). She has been written about in The New York Times, Le Monde, Newsweek, Chicago Tribune, and Los Angeles Times, and reviewed in Art News, ArtForum, Flash Art, Art Nexus,  Beaux Arts, Performance Research, Kunstforum, among others.

She was an Artist-in-Residency at Skowhegan School of Painting and Sculpture (USA); San Francisco Art Institute (USA); Khoj Artists Residency (India); Headlands Center for the Arts (USA); The Western Front (Canada); The Gasworks Studios (England); ART/OMI International Workshop (USA). Bruguera was faculty at The School of the Art Institute of Chicago from 2003 to 2010.

She received her MFAs from The School of the Art Institute of Chicago (USA) and Instituto Superior de Arte (Cuba). Her BFA is from Escuela de Arte San Alejandro (Havana, Cuba). She is the founder/director of Arte de Conducta, the first performance studies program in Latin America, hosted by Instituto Superiror de Arte in Havana. She currently lives and works between Chicago and Havana.